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KMID : 0861020120270010001
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Korea Journal of Herbology
2012 Volume.27 No. 1 p.1 ~ p.10
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The effect of Gihyeolgwanjeolbang-A(CWS-A) on adjuvant-induced arthritis in rats
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Na Chang-Su
Youn Dae-Hwan
Kim Jeong-Sang
Chae Woo-Seok
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Abstract
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Objective: To investigate effects of herbal preparations formulated(Gihyeolgwanjeolbang-A, CWS-A) on complete
Freund’s adjuvant (CFA)-induced arthritis in rats.
Method: Arthritis was induced by injecting CFA subcutaneously into the left knee joint and paw, and the herbal
preparations formulated(CWS-AⅠ, 82.3 mg/kg；CWS-AⅡ, 164.6 mg/kg) was administered orally (i.g.) for 10
consecutive days beginning on day 10 after the injection. External shape, paw edema, inflammatory cytokines
tumor necrosis factor alpha (TNF-alpha) and interleukin-1 beta (IL-1beta), and histological observation were
assessed.
Result: In swelling of the paw, CWS-AⅠ and CWS-AⅡ group in 15 days and 20 days were significantly
reduced compared to controls. In serum ALT, CWS-AⅠ and CWS-AⅡ group were significantly reduced
compared to controls. In TNF-α, CWS-AⅠ and CWS-AⅡ group were a tendency reduced compared to
controls. In HGB, HCT, MCHC of erythrocytes, CWS-AⅡ group was increased compared to controls. In
histological observations, CWS-AⅡ group was observed synoviocytes more than control group and was observed
proteoglycans in the deep layers.
Conclusion: The data suggest that CWS-A significant anti-arthritic effects that may be mediated by
suppressing inflammatory parameters.
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KEYWORD
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Arthritis, complete Freund’s adjuvant (CFA), herbal preparations, serum and blood parameters, histological observation
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